Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
نویسندگان
چکیده
منابع مشابه
Modeling psychiatric disorders with patient-derived iPSCs.
Psychiatric disorders are heterogeneous disorders characterized by complex genetics, variable symptomatology, and anatomically distributed pathology, all of which present challenges for effective treatment. Current treatments are often blunt tools used to ameliorate the most severe symptoms, often at the risk of disrupting functional neural systems, thus there is a pressing need to develop rati...
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Webster’s New World Medical Dictionary provides a simple def inition of a biomarker as “a biologic feature that can be used to measure the presence or progress of disease or the effects of treatment.” In the research literature, the term “candidate biomarker” is often loosely applied to any biological feature associated with a disorder. The search for biomarkers for psychiatric disorders has a ...
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Reprogramming of somatic cells to an embryonic-like state has dramatically changed the landscape of stem cell research. Although still in its formative stages, the field of induced pluripotent stem cells (iPSCs) has the potential to advance the study of neurodegenerative and neurodevelopmental disorders at the molecular and cellular levels. The iPSC technology could be employed to establish in ...
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Although schizophrenia affects a number of brain regions and produces a range of clinical symptoms, we believe its origins lie at the level of single neurons and simple networks. Owing to this, as well as to its high degree of heritability, we hypothesize that schizophrenia is amenable to cell-based studies in vitro. Using induced pluripotent stem cell-derived neurons and/or fibroblast-induced ...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2018
ISSN: 1756-994X
DOI: 10.1186/s13073-017-0512-3